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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
14/06/2022 |
Actualizado : |
14/06/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
JARA, E.; PEÑAGARICANO, F.; ARMSTRONG, E.; CIAPPESONI, G.; IRIARTE, A.; NAVAJAS, E. |
Afiliación : |
EUGENIO JARA, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, Montevideo 11600, Uruguay; FRANCISCO PEÑAGARICANO, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United State; EILEEN ARMSTRONG, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, 11600, Montevideo, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS IRIARTE, Laboratorio de Biología Computacional, Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, 11600, Montevideo, Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Revealing the genetic basis of eyelid pigmentation in Hereford cattle. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Journal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110 |
ISSN : |
1525-3163 |
DOI : |
10.1093/jas/skac110 |
Idioma : |
Inglés |
Notas : |
Article history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022.
Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- |
Contenido : |
ABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. MenosABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed se... Presentar Todo |
Palabras claves : |
Beef cattle; Melanocyte biology; Ocular pathologies. |
Asunto categoría : |
L01 Ganadería |
Marc : |
LEADER 03180naa a2200253 a 4500 001 1063291 005 2022-06-14 008 2022 bl uuuu u00u1 u #d 022 $a1525-3163 024 7 $a10.1093/jas/skac110$2DOI 100 1 $aJARA, E. 245 $aRevealing the genetic basis of eyelid pigmentation in Hereford cattle.$h[electronic resource] 260 $c2022 500 $aArticle history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022. Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- 520 $aABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. 653 $aBeef cattle 653 $aMelanocyte biology 653 $aOcular pathologies 700 1 $aPEÑAGARICANO, F. 700 1 $aARMSTRONG, E. 700 1 $aCIAPPESONI, G. 700 1 $aIRIARTE, A. 700 1 $aNAVAJAS, E. 773 $tJournal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas; INIA Tacuarembó. |
Fecha actual : |
21/02/2014 |
Actualizado : |
18/06/2021 |
Tipo de producción científica : |
Documentos |
Autor : |
PRITSCH, C.; MAZZELLA, C.; QUEZADA, M.; DA CRUZ, I.; VÁZQUEZ, S.; GAIERO, P.; VAIO, M.; SILVA, P.; BACCINO, E.; LOMBARDO, P.; HINRICHSEN, P.; GARCIA, A.A.F.; CABRERA, D.; VIGNALE, B. |
Afiliación : |
Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Biologia Vegetal, Fac.Agronomía, UdelaR.; Depto de Produccion Vegetal, Fac. Agronomia, UdelaR.; INIA La Platina (Chile); ESALQ-USP (Brasil); CARLOS DANILO CABRERA BOLOGNA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Depto de Produccion Vegetal, Fac. Agronomia, UdelaR. |
Título : |
Avances en estudios genómicos en guayabo del país (Acca sellowiana). |
Fecha de publicación : |
2012 |
Fuente / Imprenta : |
In: INIA, Programa Nacional Investigación Producción Frutícola; Universidad de la República (UdelaR), Facultad de Agronomía; MGAP, DGF (Dirección General Forestal). Encuentro Nacional de Frutos Nativos, 6. Canelones (Uruguay): INIA, 2012. |
Páginas : |
p.16-22 |
Serie : |
(INIA Serie Actividades de Difusión; 679) |
Idioma : |
Español |
Palabras claves : |
GUAYABO DEL PAÍS. |
Thesagro : |
ACCA SELLOWIANA; GENETICA; GENOMICA. |
Asunto categoría : |
-- |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/2363/1/18429030512102227.pdf;#page=19
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Marc : |
LEADER 01085naa a2200337 a 4500 001 1009377 005 2021-06-18 008 2012 bl uuuu u00u1 u #d 100 1 $aPRITSCH, C. 245 $aAvances en estudios genómicos en guayabo del país (Acca sellowiana). 260 $c2012 300 $ap.16-22 490 $a(INIA Serie Actividades de Difusión; 679) 650 $aACCA SELLOWIANA 650 $aGENETICA 650 $aGENOMICA 653 $aGUAYABO DEL PAÍS 700 1 $aMAZZELLA, C. 700 1 $aQUEZADA, M. 700 1 $aDA CRUZ, I. 700 1 $aVÁZQUEZ, S. 700 1 $aGAIERO, P. 700 1 $aVAIO, M. 700 1 $aSILVA, P. 700 1 $aBACCINO, E. 700 1 $aLOMBARDO, P. 700 1 $aHINRICHSEN, P. 700 1 $aGARCIA, A.A.F. 700 1 $aCABRERA, D. 700 1 $aVIGNALE, B. 773 $tIn: INIA, Programa Nacional Investigación Producción Frutícola; Universidad de la República (UdelaR), Facultad de Agronomía; MGAP, DGF (Dirección General Forestal). Encuentro Nacional de Frutos Nativos, 6. Canelones (Uruguay): INIA, 2012.
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